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Atrial Natriuretic Peptide: A Molecular Target of Novel Therapeutic Approaches to Cardio-Metabolic Disease

By blocking NNMT activity, it increases critical cellular metabolites (SAM, NAD) that drive downstream increases in energy expenditure and metabolic health 1-4

Observed mean body weight (kg) over time for participants in the full analysis set during the in-trial observation period (from randomization to last contact with trial site, regardless of treatment discontinuation or rescue intervention)

Despite the promising efficacy observed in Th- MYCN -derived 3D spheres, administration of the compounds resulted in gastrointestinal toxicity, including blocked intestine and stomach enlargement, necessitating early termination of the experiment

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