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A high intracellular ratio of reduced glutathione to oxidized glutathione (GSH/GSSG ratio) is protective of microtubules in their polymerized state by the preventing oxidation of cysteine residues in tubulin subunits

For the colorectal cancer PDX study, female NCR nude mice (CrTac:NCr- Foxn1 nu from Taconic) were implanted subcutaneously with low-passage KRAS-mutant CRM 13180 tumour fragments (30 mg) into the region of the right axilla

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[DOI] [PubMed] [Google Scholar] 29.Gluchowski N.L., Gabriel K.R., Chitraju C., Bronson R.T., Mejhert N., Boland S., Wang K., Lai Z.W., Farese R.V., Jr., Walther T.C