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Beyond its primary roles in hydrochloric acid secretion and pepsinogen-mediated protein digestion, this niche also functions as a biological filter that restricts microbial passage

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The neurotoxic effects of mHtt are mediated by the induction of mitochondrial defects, which in turn result in aberrant energy metabolism and HD-related neuronal dysfunction ( Studies have demonstrated that mHTT interacts with the PGC-1 promoter, directly impairs the activity of PGC-1, and impedes the capacity of PGC-1 to open downstream target genes (Cui et al., 2006