Sacchi S, Kantarjian HM, Smith TL, O'Brien S, Pierce S, Kornblau S, Beran M, Keating MJ, Talpaz M
A series of equations illustrating the Merrifield synthesis may be viewed by clicking on the following diagram
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The peptide has been characterized in tendon, ligament, muscle, gut, vascular, neural and bone injury models, where it consistently accelerates structural recovery, restores barrier function and rescues vascular perfusion through a coordinated upregulation of growth factor receptors, the nitric oxide system and angiogenic signaling [13]