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Overall, while tumours can exploit NAD+, restoring normal NAD+ levels in healthy individuals does not trigger cancer

The (KLAKLAK)2 peptide fused with the IL4R-binding IL4RPep-1 peptide (CRKRLDRNC) exhibited selective cytotoxicity toward IL4R-expressing tumor cells and enhanced the sensitivity of cells to chemotherapy 53

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Further CC and CN bond forming reactions that have been developed for small molecule aryl bromides can similarly be adapted for halogenated peptides and proteins with rigourous screening of catalysts and reaction conditions