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Astrotauopathies drive the pathophysiology of progressive supranuclear palsy, corticobasal degeneration, Picks disease, argyrophilic grain disease, globular glial tauopathies, and ageing-related tau astrogliopathy (ARTAG)

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Preclinical studies indicate potential roles in: Supporting healthy fat metabolism and reduction of adipogenesis Improving insulin sensitivity in metabolic research models Enhancing NAD+ salvage pathway efficiency Exploring effects on energy homeostasis and longevity pathways These findings remain preliminary and confined to laboratory and animal models