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This work is supported by the National Key Research & Development Program (2022YFC2603900), Beijing Natural Science Foundation (JQ24055), and the National Natural Science Foundation of China (22175189, 52373127)

Among 38 identified hits, we found a subset of chloroacetamides with broad senolytic activity

Besides, usages for depletion of GST (glutathione sepharose) after cleavage from recombinant fusion proteins and affinity purification of GST-tagged proteins are possible