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Figure 3 It has been reported that Sorafenib inhibits the Xc- system transport of cysteine, leading not only to ferroptosis but also inducing ERS, such as eIF2 phosphorylation, and upregulation of ATF4 and cation transport-regulated homologue 1 ( The activation of the PERK-eIF2-ATF4-CHOP pathway mediated by ERS promotes p53 expression and is involved in the interaction between ferroptosis and apoptosis

The four degradation factors are heat fluctuation, light and UV exposure, repeated freeze-thaw cycles, and contamination from non-sterile technique

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IV nutrient therapy is not appropriate for every cancer patient

Mitochondrial homeostasis Carnitine pool homeostasis plays an important role in maintaining mitochondrial function and integrity [12, 13]