575 Similarly, the loss of mitochondrial complex I leads to a decrease in the ratio of NAD + /NADH and can inhibit the activity of Sirt3, thereby enhancing the protein acetylation and mPTP sensitivity
Santos AL, et al
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Xiao et al., 2005
Under conditions in which the GPx activity is rate limiting, the rate of decrease in the A340 is directly proportional to the GPx activity in the sample (35)